NAD+??????????????????????NAD+????????SIRT3????????? SIRT3???????OXPHOS?????ATP?????????????????????????CypD???????????????? SIRT3-Ko???13???????????????????????????????????NMN?????????????? ??????30??500 mg/kg?i.p.???????????????????NAMPT????NMN??????????????????????????????44%?? NAD+?????????????MDX???????????? nmn??nmn??? NAD+???????????????????